Folding RNA: Influenza

描述（由申请人提供）：本研究将在罗切斯特大学和位于波兰波兹南的波兰科学院生物有机化学研究所进行。这项工作将与道格拉斯H.特纳在罗切斯特大学作为美国国立卫生研究院批准号RO 1GM 22939，8-15-2008至7-31-2012的扩展，并将包括在罗切斯特大学（D.H.马修斯肯尼迪和B。金博士）和布法罗的纽约州立大学（医学博士）。迪士尼）。这项研究将由Elzbieta Kierzek博士完成，他相当于波兹南生物有机化学研究所的助理教授。这项工作的目标是改进预测和确定流感病毒RNA二级结构的方法，并发现可以导致流感RNA治疗的化合物。 公共卫生相关性：具有RNA基因组的病毒导致许多疾病，包括流感。该项目研究快速确定流感RNA结构的方法，并发现能够治疗靶向RNA的化合物。

DESCRIPTION (provided by applicant): This research will be done at the University of Rochester and the Polish Academy of Sciences Institute of Bioorganic Chemistry in Poznan, Poland. The work will be in collaboration with Prof. Douglas H. Turner at the University of Rochester as an extension of NIH Grant No. RO1GM22939, 8-15-2008 to 7-31-2012, and will include additional collaborators at the University of Rochester (D.H. Mathews, S.D. Kennedy, and B. Kim) and at the State University of New York at Buffalo (M.D. Disney). The research will be done by Dr. Elzbieta Kierzek, who is the equivalent of an Assistant Professor at the Institute of Bioorganic Chemistry in Poznan. The goals of the work are to improve methods for predicting and determining the RNA secondary structures of influenza virus and to discover compounds that can lead to therapeutics for influenza RNA. PUBLIC HEALTH RELEVANCE: Viruses with RNA genomes are responsible for many diseases, including influenza. This project studies methods to determine rapidly the structures of influenza RNA and to discover compounds capable of therapeutically targeting the RNA.