Effect of Diet on Vascular Disease: Study of African American & Caucasian Women

在这项研究中，我们将招募96名女性（48名非裔美国女性和48名高加索女性）。我们招收年龄在18岁到64岁之间的女性。这项研究将涉及到NIH临床中心的几次门诊访问。第一次访问将是一个筛选，以确定资格。在第二次就诊时，将进行胰岛素抵抗测试。该试验称为频繁取样静脉葡萄糖耐量试验。第三次访问将是测试餐。餐前、餐后2、4、6小时抽血，测量血管功能。血管功能是通过测量血压，然后用超声波测量手臂的血流量来确定的。饮食的个体差异可能会影响试验餐当天血管研究的结果。因此，在测试餐前7天，NIH临床中心将以托盘或盒装餐的形式为每位参与者提供所有膳食。这些食物将由典型的美国饮食组成，其中33%的脂肪，15%的蛋白质和52%的碳水化合物。在设计这些膳食时，营养师会考虑到个人的食物偏好。目前已有26名女性（16名非裔美国人和16名高加索人）完成了这项研究。登记和分析已经收集到的数据正在进行中。

For this study we will enroll 96 women (48 African American and 48 Caucasian women). We are enrolling women between the ages of 18 and 64 years. The study will involve several outpatient visits to the NIH Clinical Center. The first visit will be a screening to determine eligibility. At the second visit a test will be performed to measure insulin resistance. This test is called a frequently sampled intravenous glucose tolerance test. The third visit will be for the test meal. Before and at 2, 4 and 6 hours after the meal, blood will be drawn and vascular function measured. Vascular function is determined by taking blood pressure and then measuring blood flow in the arm with ultrasound. It is possible that individual differences in diet could affect the results of the vascular study on the day of the test meal. Therefore for 7 days prior to the test meal, the NIH Clinical Center will provide to each participant all their meals in the form of either trays or meals in a box. These meals will consist of the typical American diet and be 33% fat, 15% protein and 52% carbohydrate. In designing these meals, the dietician will take into account individual food preferences. Twenty-six women (16 African American and 16 Caucasian) have now completed the study. Enrollment and analysis of data already collected is underway.