Training in Schizophrenia and Psychotic Disorders: From Animal Models to Patients

描述（由申请人提供）：这是一份申请，申请资助T32-MH 018870，精神分裂症研究奖学金，自1988年以来一直持续资助。该提案的主要目标是培养博士后（MD，MD/PhD和PhD）研究员作为精神分裂症的独立研究人员。一个密集的三年计划概述了研究员将学习如何确定关键的研究问题，制定假设，设计和执行实验，有效地测试这些假设。在培训过程中，研究员将获得一系列与研究方法相关的技能，包括与基础，转化和临床研究计划相关的实验设计和统计分析方面的专业知识。毕业研究员将能够以书面和口头形式清楚地介绍整个项目，并通过出版物和演讲证明。 培训计划的成功最好是由我们以前的学员取得的卓越成就来判断。在过去的10年里，27名研究员被选中进入培训计划，55%的MD，30%的MD/PhD和15%的PhD。59%的学员是女性。未来的研究员专门申请这个项目，培训名额的竞争仍然激烈。26%的研究员是从哥伦比亚精神病学住院医师项目中招募的。在过去的10年中，奖学金的毕业率为100%（21/21）。目前，有6名研究员：1名四年期研究员（因怀孕和产假而获得特别豁免）、1名三年期研究员、2名二年期研究员和2名一年期研究员; 4名新研究员已被接受，将于2009年底前开始工作。在过去10年毕业的21名研究员中，有11名（52%）获得了K奖，目前正在审查现有研究员提交的两份K奖。两名毕业生（10%）已经收到R 01，另外两名收到R21（ROI和R21合计19%），还有几名正在等待申请。总共有18名（86%）毕业生获得了大量的独立资助，包括ROI，K奖，R 03奖，R21奖，NARSAD奖以及海军研究办公室和其他资助机构的赠款。在21名毕业于该计划的研究员中，有16名（76%）担任全职学术研究职位。 没有培训计划可以保持一个成功的跟踪记录，如果它仍然停滞不前;它必须适应环境的变化和精神病学转化研究方面不断增长的机会。通过加强教学计划和通过在这一领域战略性地增加教师导师，翻译研究的培训得到了显着加强。这个培训项目的最大优势一直是哥伦比亚的教师和精神病学系内外的研究环境。今天仍然如此，培训计划的核心已经通过当前应用程序的变化得到了加强。 精神分裂症是一种毁灭性的疾病，给患者、家庭和社会带来负担。这项拨款旨在培训精神病学家和科学家研究精神分裂症的原因和开发新的治疗方法。

DESCRIPTION (provided by applicant): This is an application for renewal of grant T32-MH018870, Schizophrenia Research Fellowship, which has been funded continuously since 1988. The primary goal of this proposal is to train postdoctoral (MD, MD/PhD and PhD) fellows for careers as independent researchers in Schizophrenia. An intensive three-year program is outlined in which fellows will learn how to identify key research questions, formulate hypotheses, and design and execute experiments that effectively test those hypotheses. In the course of training, fellows will acquire a range of skills relevant to research methodology, including expertise in experimental design and statistical analysis relevant to basic, translational and clinical research programs. Graduating fellows will be able to present clearly an entire project in both written and oral form as evidenced by publications and presentations. The success of the training program is best judged by the remarkable accomplishments of our former trainees. In the past 10 years, 27 fellows have been selected to enter the training program, 55% MDs, 30% MD/PhDs and 15% PhDs. 59% of our trainees have been women. Prospective fellows apply specifically to this program, and the competition for training slots remains intense. 26% of fellows have been recruited from the Columbia Psychiatry Residency program. The graduation rate of the fellowship is 100% over the last 10 years (21/21). Currently, there are six fellows: one fourth-year (special waiver related to a complicated pregnancy and maternity leave), one third-year, two second-year and 2 in the first year of training; four new fellows have been accepted to begin before the end of 2009. Of the 21 fellows who have graduated the program in the past 10 years, 11 (52%) have received K awards and two K award submissions are presently under review from current fellows. Two graduates (10%) have already received R01s with another two receiving R21s (total of 19% for both ROIs and R21s), and several others have applications pending. In total, 18 (86%) graduates have received substantial independent funding including ROIs, K awards, R03 awards, R21 awards, NARSAD awards, and grants from the Office of Naval Research and other funding agencies. Of the 21 fellows who graduated the program, 16 (76%) are in full-time academic research positions. No training program can maintain a successful track record if it remains stagnant; it must adapt to changes in circumstances and the growing opportunities in terms of translational research in Psychiatry. The training in translational research has been markedly strengthened by enhancement of the didactic teaching program and through the strategic addition of faculty mentors in this area. The greatest strengths of this training program have always been Columbia's faculty and the research environment within the Department of Psychiatry and beyond. This remains the case today, and the core of the training program has been strengthened by the changes in the current application. PUBLIC HEALTH RELEVANCE: Schizophrenia is a devastating illness that places a burden on patients, families and society. This grant aims to train psychiatrists and scientists to study schizophrenia's causes and to develop new treatments.