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Analysis of tumor cell death on antigen-specific immune responses

Analysis of tumor cell death on antigen-specific immune responses
肿瘤细胞死亡对抗原特异性免疫反应的分析
批准号：
8175347
负责人：
Tim Greten
金额：
$17.22万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8175347
关键词：
AntigensApoptoticCD8B1 geneCell DeathCellsDataGenerationsImmune responseIn VitroInduction of ApoptosisMolecularNecrosisPatternSystemT-Cell ActivationT-Lymphocytebaseimmunogenicin vivoneoplastic cellresponsetumor

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中文摘要
翻译
肿瘤细胞死亡的方式被认为对适应性免疫反应的产生有重大影响。在我们以前的研究中，我们已经能够证明，在皮下生长的肿瘤中，诱导凋亡和坏死对肿瘤特异性CD8+T细胞有明显不同的影响。而凋亡性肿瘤细胞死亡促进抗肿瘤免疫反应，而坏死性肿瘤细胞死亡则削弱这些反应。基于这些体内发现，我们已经能够建立一个体外系统，允许更详细地剖析导致这些观察的免疫学机制。
英文摘要
The way in which tumor cells die is proposed to have a substantial impact on the generation of adaptive immune responses. In our previous studies we have been able to demonstrate that induction of apoptosis versus necrosis in subcutaneously growing tumors has prfoundly different effects on tumor specific CD8+ T cells. While apoptotic tumor cell death promote anti-tumor immune responses necrotic tumor cell death impair these responses. Based on these in vivo findings we have been able to establish an in vitro system, which allows to dissect the immunological mechanisms responsible for these observations in more detail.
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