Electron Microscopy Laboratory

国家癌症研究所的图像分析实验室(IAL) - Frederick专注于定量显微镜的研究，通过分析单个细胞中分子通路的动力学来了解实体肿瘤的癌变过程，同时细胞保持在其组织环境中。研究主要由多个NCI首席研究员合作完成，特别强调STAT3蛋白在细胞质和细胞核中的作用。技术发展还旨在为从分子到动物水平的多个尺度的生物样品分析提供综合资源，从而在基础研究和转化研究之间提供无缝的双向过渡。IAL在初夏收到了出色的实地考察审查。IAL在行政上分为两部分：共聚焦显微镜（CM）和电子显微镜（EM）；因此，每个部分单独报告。

The Image Analysis Laboratory (IAL) at the National Cancer Institute - Frederick focuses research on quantitative microscopy for understanding carcinogenesis in solid tumors by analyzing the kinetics of molecular pathways in individual cells while cells remain in their tissue context. Research is done mostly by collaborations with multiple NCI principal investigators, with special emphasis on the cytoplasmic and nuclear roles of the protein STAT3. Technical developments also aim to provide an integrated resource for analysis of biological samples across multiple scales from molecular to the animal level, thus providing a seamless, bidirectional transition between basic and translational research. IAL received an outstanding site visit review in the early summer. IAL is administratively divided into two parts: confocal microscopy (CM) and electron microscopy (EM); therefore, each part is reported separately.