ES Cell & Transgenics

转基因小鼠模型对科赫研究所成员的研究项目至关重要。他们 用于探索癌症基因在细胞和发育生物学中的作用，研究肿瘤基因的作用机制 肿瘤的发展、进展和转移，药物反应和耐药性的评估，以及测试新药 肿瘤检测和药物输送的策略和设备。ES细胞和转基因核心是一种 机构共享资源，为科赫研究所的研究人员提供咨询建议、技术 支持和/或培训工程细胞和小鼠模型的生产。在本期内， 这一核心的能力得到了进一步的扩展和增强。这包括搬进一个更大的、 在新的科赫研究所大楼中定制设计的空间，增加新的服务和重组 工作人员为新手用户提供支持，并提供项目定制服务。值得注意的是，在同一时期，使用 包括调查人员在内，中心成员对ES细胞和转基因核心的比例从29%增加到51% 来自所有四个项目。因此，这种共享资源对于科赫研究所任务的成功至关重要。 在接下来的一段时间里，ES细胞和转基因核心将继续提供各种最先进的 为中心成员的研究项目提供支持的服务。尽管服务显著扩展， 和使用，请求的CCSG 44年预算比请求和建议的预算低13% 39年的财政预算。

Genetically engineered mouse models are critical for the research programs of Koch Institute Members. They are used to probe the role of cancer genes in cell and developmental biology, investigate the mechanisms of tumor development, progression and metastasis, evaluate drug response and resistance, and test novel strategies and devices for tumor detection and drug delivery. The ES Cell & Transgenics Core is an Institutional Shared Resource that provides Koch Institute investigators with consultative advice, technical support and/or training in the production of engineered cells and mouse models. In the current period, the capabilities of this Core have been further expanded and enhanced. This includes moving into a larger, custom-designed space in the new Koch Institute building, the addition of new services and a reorganization of the staff to support novice users and provide project-customized services. Notably, in the same period, usage of the ES Cell & Transgenics Core by Center Members increased from 29% to 51%, including investigators from all four programs. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, the ES Cell & Transgenics Core will continue to offer a wide range of state-of-the-art services to support the research programs of Center Members. In spite of the significant expansion of services and usage, the requested CCSG budget for Year 44 is 13% lower than the requested and recommended budget in Year 39.