Clinical and Translational Science Collaborative of Cleveland

克利夫兰的临床和转化科学合作（CTSC）是克利夫兰五个卫生机构之间的合作企业-凯斯西储大学，克利夫兰诊所，大学医院，MetroHealth医疗中心和退伍军人管理局医疗中心，以及社区合作伙伴。CTSC实现了作为一个协作单位联合起来的先前目标，开发了信息学工具，共享了资源，并作出了机构承诺，以加强协作。将继续开展上一个赠款期开始的巩固和促进活动。此外，反恐委员会将继续严格评估其业务和实现更大目标的进展情况。CTSC为下一个赠款期设定了三个新目标。“1）翻译研究将得到加强。将实施支持治疗靶点的鉴定和结构确定以及高通量筛选的基础设施。将精简和加强支持系统，以协助以病人为基础的研究，包括招募和测试。关键是，CTSC将创建支持系统，以指导潜在的人类治疗和诊断的开发，从发现到用于人类，2）CTSC将改善克利夫兰的健康参数，克利夫兰是美国最贫穷和最不健康的城市之一。社区研究伙伴关系核心是通过社区焦点小组查询社区，以确定他们的健康优先事项。这些优先事项中至少有一个，以及根据我们CTSC调查界的优势选择的其他优先事项，将成为特别努力的目标。一个以实践为基础的研究网络已经成功地在三年内将克利夫兰27，000名糖尿病患者的HgbAlc降低了一个百分点，这让人乐观地认为该项目确实可以移动针。3)CTSC与国家CTSA社区的互动将增加。CTSC最初的重点是向内，建立联系和催化我们的家乡机构的变化，但在下一个赠款期间，CTSC将增加围绕联盟的互动。一个主要的重点将是俄亥俄州联盟的三个俄亥俄州CTSA（CTSC，哥伦布，辛辛那提），目前合作的儿童健康和癌症项目，并在网站NetWellness，这已经从简单地提供公正的医疗信息，包括临床研究和获得临床试验的描述。在下一个资助期内，目标将包括扩展CTSC IRB电子中心，以促进审查，包括其他CTSA网站，增加项目合作，并通过Explorys连接患者数据库，Explorys是一种利用电子健康记录的基于网络的信息学工具。

The Clinical and Translational Science Collaborative (CTSC) of Cleveland is a collaborative venture among five Cleveland health institutions - Case Western Reserve University, the Cleveland Clinic, University Hospitals, MetroHealth Medical Center, and the Veterans Administration Medical Center, as well as community partners. CTSC achieved prior goals of uniting as a collaborative, developed informatics tools, resource sharing, and institutional commitments to enhance the collaborative. Consolidation and catalytic activities begun in the last grant period will be continued. Moreover, CTSC will continue rigorous evaluation of both its operations and progress toward larger goals. CTSC has set three new goals for the next grant period.' 1) Translation 1 research will be enhanced. Infrastructure in support of identification and structural determination of therapeutic targets, as well as high through put screening will be implemented. Support systems to assist in patient based research both recruitment and testing will be streamlined and strengthened. Critically, CTSC will create support systems to guide development of potential human therapeutics and diagnostics from discovery to use in man, 2) CTSC will improve health parameters in Cleveland, one of America's poorest and least healthy cities. Community Research Partnership Core is querying the community via neighborhood focus groups to determine their health priorities. At least one of these priorities, and others selected based on the strengths of our CTSC investigative community, will be targeted for special effort. One practice based research network has already succeeded in reducing HgbAlc in 27,000 diabetics in Cleveland by one percentage point in three years, raising optimism that this project can indeed move the needle. 3) CTSC interactions with the national CTSA community will increase. The initial focus of CTSC was inward, establishing connections and catalyzing change in our home institutions, but in the next grant period the CTSC will increase interactions around the consortium. A primary focus will be the Ohio Consortium of the three Ohio CTSAs (CTSC, Columbus, Cincinnati), which currently collaborate surrounding child health and cancer projects, and on the web site NetWellness, which has been expanded from simply providing unbiased medical information to include descriptions of clinical research and access to clinical trials. In the next grant period goals will include extending the CTSC IRB electronic hub for facilitated review to include the other CTSA sites, increasing project collaboration, and connecting patient databases via Explorys, a web based informatics tool utilizing the electronic health record.