Xenbase: The Xenopus model organism database

 描述（由申请人提供）：Xenbase，非洲爪蟾模式生物数据库，是一个网络可访问的资源，整合了非洲爪蟾研究的所有不同的基因组和生物学数据。Xenbase的目标是增强非洲爪蟾研究的能力，提高非洲爪蟾研究数据的影响力，并促进这些数据的传播。非洲爪蟾蛙是生物医学研究的主要脊椎动物模型之一。人类和模式生物（如非洲爪蟾）之间的比较功能基因组学已经导致了大量的发现，在这个后基因组时代，每年有数千篇科学出版物和大规模数据集的指数增长，像Xenbase这样的资源对于将这些庞大的数据转化为有意义的生物合成至关重要。Xenbase是唯一一个存储Xenopus研究所产生的大量数据的中央存储库。我们的关系数据库和用户友好的界面使这些数据易于查询，并允许调查人员以其他困难，耗时或不可能的方式快速查询和链接不同的数据类型。Xenbase还通过高质量的策展、数据整合、提供针对爪蟾实验优化的生物信息学工具以及将爪蟾数据与人类和其他模式生物联系起来，提高了爪蟾数据的价值。Xenbase通过不断向NCBI、UniProtKB和Enclave等组织提供注释数据更新，在使更广泛的生物医学界能够访问Xenopus数据方面发挥着不可或缺的作用。Xenbase加速了发现，使研究人员能够在非洲爪蟾的分子途径和人类疾病之间建立新的联系。Xenbase在最大化NIH每年约1.3亿美元的非洲爪蟾研究投资方面发挥着重要作用。本提案的目标是维护和扩展Xenbase。我们的目标是通过社区的广泛投入制定的：目标1维护Xenbase并继续管理Xenopus研究数据目标2为人类疾病的Xenopus模型提供支持目标3加强对新数据类型、生物信息学工具和数据共享基础设施的支持

 DESCRIPTION (provided by applicant): Xenbase, the Xenopus model organism database, is a web accessible resource that integrates all the diverse genomic and biological data from Xenopus research. The goal of Xenbase is to empower Xenopus research, enhance the impact of Xenopus research data and to facilitate the dissemination of this data. Xenopus frogs are one of the major vertebrate animal models used for biomedical research. Comparative functional genomics between humans and model organisms such as Xenopus have led to a wealth of discoveries and in this post genomic era and with thousands of scientific publications annually and the exponential growth of large-scale datasets, resources such as Xenbase are essential to translate this vast body of data into a meaningful biological synthesis. Xenbase is the only central repository for the enormous amount of data generated from Xenopus research. Our relational database and user-friendly interface make this data easy to query, and allows investigators to quickly interrogate and link different data types in ways that would otherwise be difficult, time consuming, or impossible. Xenbase also enhances the value of Xenopus data through high quality curation, data integration, providing bioinformatics tools optimized for Xenopus experiments, and by linking Xenopus data to humans and other model organisms. Xenbase plays an indispensable role in making Xenopus data accessible to the broader biomedical community by continually providing annotated data updates to organizations such as NCBI, UniProtKB and Ensemble. Xenbase accelerates discovery, enabling investigators to make novel connections between molecular pathway in Xenopus and human disease. Xenbase plays an essential role in maximizing the NIH's ~$130 million annual investment in Xenopus research. The Goal of this proposal is to maintain and expand Xenbase. Our Aims, developed through extensive input from the community are: Aim1 Maintain Xenbase and continue curation of Xenopus research data Aim 2 Develop support for Xenopus models of human diseases Aim 3 Enhance support for new data types, bioinformatics tools and data sharing infrastructure