Phase 3B of a 3-phase 1.3-GHz LTS/HTS NMR magnet

标题：三相1.3 GHz LTS/HTS核磁共振磁体的改进3B相 申请号：GM114834-11A1 岩泽幸子，弗朗西斯苦磁体实验室，等离子体科学和核聚变 麻省理工学院中心，麻省理工学院，剑桥 日期：2015年8月10日 新摘要信息 在核磁共振最简单的观点中，高场的优点是提高了灵敏度和 决议。光谱学基本上包括测量频率和幅度。分辨率 提供频率信息。敏感度提供幅度信息。每单位时间的敏感度 在信号平均实验中，3D实验的分辨率比ω3更高。因此， 例如，在频率方面，从800 MHz到1.3 GHz，灵敏度和分辨率提高了 系数为4.3。大多数蛋白质溶液核磁共振实验利用TROSY效应来 优化实验的分辨率。最初有人预测TROSY实验 在~900兆赫会是最佳的。然而，最近的实验数据和模拟 几种蛋白质表明，分辨率在1200-1400 MHz范围内是最佳的(见 下文)。在魔角旋转(MAS)固态核磁共振中，场强越大越理想。 许多前沿结构生物学问题，如核糖体蛋白合成、病毒入侵 进入细胞，与人类疾病有关的离子通道，将变得可以通过固态核磁共振 在较高磁场下的研究。这一修改后的3B阶段计划有两个具体目标： 目标1)成功完成800-MHz(18.79 T)高温超导插件(H800)，包括3个嵌套 成堆的DP线圈用GdBCO磁带缠绕，连同500 MHz(11.74T)LTS核磁共振 FBML提供的磁铁(L500)将产生30.53T(1.3 GHz 1H频率)的磁场； 目标2)从阶段3A继续开发创新的场垫补技术，以 在完成此修改的3B阶段计划后，将30.53-T L500/H800磁体转换为 高分辨率1.3 GHz核磁共振磁体(1.3克)，能够产生1赫兹的线宽。这些新的 对于依赖高温超导插件的核磁共振磁体来说，场匀场技术是必不可少的。要实现 目标1以最高效、最实惠的方式，我们正在应用创新的设计理念 制造高温超导双薄饼(DP)线圈：无绝缘绕组技术和内凹槽DP 线圈。两种新的垫片技术，其发展将继续作为目标2在这里 修改后的3B阶段计划是永续模式高温超导垫片和“摇动场”磁铁。vt.在.的基础上 成功完成我们的1.3G，它将安装在麻省理工学院-哈佛磁学中心 FBML的共鸣。我们相信，我们的1.3代将成为高场核磁共振领域的一支生力军 将在未来几十年为美国的整个核磁共振社区提供服务，并在全球范围内 对医学科学的影响。 修改后的特定目标 800-MHz(18.79 T)高温超导插件(H800)成功完成，包括3个嵌套 用GdBCO胶带缠绕的DP线圈堆叠是修改后的3B期的具体目标之一 程序。H800将与500-MHz(11.74吨)LTS核磁共振磁铁(L500)相结合 目前在FBML有售。在修改后的第3B阶段计划中，我们还将继续 在阶段3A启动的新现场垫片技术的开发。在完成这项工作后 修改了3B阶段计划，我们将对H800应用垫片技术，从而 将合成的30.53-T LTS/HTS磁体转换为高分辨率1.3 GHz核磁共振磁体 (1.3克)。1.3 GHz磁体的主要优点是更高的分辨率和灵敏度。这将使 对蛋白质和核酸等复杂分子系统的大量研究 更短的时间，或者用更少的材料。 修改后的3B阶段计划有两个具体目标：1)成功完成H800，即 与L500一起产生30.53T的磁场和1.3 GHz的1H频率；2) 从阶段3A继续开发磁场垫片技术，以在完成后进行转换 在这个修改的3B阶段计划中，30.53-T L500/H800磁体到高分辨率1.3 GHz 核磁共振磁铁(1.3克)，能够产生1赫兹的线宽。这些新的场垫补技术 对于依赖高温超导带状导体的核磁共振磁体来说是必不可少的。正如在3中进一步讨论的那样。 研究与战略，以最有效、最实惠的方式实现目标1，我们正在 应用创新的设计理念制造高温超导DP线圈：无绝缘绕组技术和 内槽DP线圈。为了确保尽可能高的概率实现目标2，我们有 在阶段3A启动，并在修改后的阶段3B计划中继续开发两个 创新的磁场垫片技术：持久模式高温超导垫片和“摇动磁场”磁铁。AS 在3.研究与战略中也有讨论，L500/H800组合的数量要少得多 比4.2-K操作的900 MHz LTS磁铁(L900)和400 MHz LTS磁铁的组合更贵。 MHz HTS插件(H400)-当HTS插件成为 &gt；1 GHz核磁共振磁铁。此外，由于1-GHz LTS/HTS磁体的占地面积是 基本上由LTS组件决定，我们的L500/H800组合在空间上是 比L900/H400组合更有效，当然也更令人满意。 已修改

Title: Modified Phase 3B of a 3-phase 1.3-GHz LTS/HTS NMR magnet Application #: GM114834-11A1 PI: Yukikazu Iwasa, Francis Bitter Magnet Laboratory, Plasma Science and Fusion Center, Massachusetts Institute of Technology, Cambridge MA Date: August 10, 2015 New Abstract Information In the simplest view of NMR, the advantages of higher field are improved sensitivity and resolution. Spectroscopy basically consists of measuring frequencies and amplitudes. Resolution gives frequency information. Sensitivity gives amplitude information. Both sensitivity per unit time in signal averaging experiments and resolution for 3D experiments improve as ω3. Thus, going up in frequency, for example, from 800 MHz to 1.3 GHz, sensitivity and resolution scale up by a factor of 4.3. In solution NMR most protein solution NMR experiments utilize the TROSY effect to optimize the resolution of the experiments. Initially it was predicted that TROSY experiments would be optimal at ~900 MHz. However, more recent experimental data and simulations on several proteins indicate that the resolution is optimized in the range 1200—1400 MHz (vide infra). In magic-angle-spinning (MAS) solid-state NMR, the higher the field the more optimal. Many cutting-edge structural biology questions such as ribosomal protein synthesis, virus entry into cells, ion channels implicated in human diseases, will become accessible to solid-state NMR investigation at higher magnetic fields. This modified Phase 3B program has two specific aims: Aim 1) successful completion of an 800-MHz (18.79 T) HTS insert (H800) comprising 3 nested stacks of DP coils wound with GdBCO tape, that together with a 500-MHz (11.74 T) LTS NMR magnet (L500) available at the FBML, will generate a field of 30.53 T (1.3 GHz 1H frequency); Aim 2) development, continued from Phase 3A, of innovative field-shimming techniques to convert, after completion of this modified Phase 3B program, the 30.53-T L500/H800 magnet to a high-resolution 1.3 GHz NMR magnet (1.3G) capable of producing 1-Hz linewidths. These new field-shimming techniques are essential for NMR magnets that rely on an HTS insert. To achieve Aim 1 in the most efficient, and affordable, manner, we are applying innovative design concepts to build HTS double-pancake (DP) coils: no-insulation winding technique and inside-notch DP coils. The two new shimming techniques, development of which will be continued as Aim 2 in this modified Phase 3B program are persistent-mode HTS shims and “shaking-field” magnet. Upon successful completion of our 1.3G, it will be installed in the MIT-Harvard Center for Magnetic Resonance at the FBML. We believe that our 1.3G will become a vital force in high-field NMR and will serve the entire NMR community in the U.S. for decades to come and have a worldwide impact on medical sciences. Modified Specific Aims The successful completion of an 800-MHz (18.79 T) HTS insert (H800) comprising 3 nested stacks of DP coils wound with GdBCO tape, is one of the Specific Aims of this modified Phase 3B program. The H800 will be combined with a 500-MHz (11.74 T) LTS NMR magnet (L500) presently available at the FBML. In this modified Phase 3B program we will also continue development, initiated in Phase 3A, of new field shimming techniques. After completion of this modified Phase 3B program, we will apply the shimming techniques to the H800, thereby converting the resultant 30.53-T LTS/HTS magnet to a high-resolution 1.3-GHz NMR magnet (1.3G). The key benefits of a 1.3-GHz magnet are higher resolution and sensitivity. This enables the examination of complex molecular systems such as proteins and nucleic acids in a much shorter time, or with smaller quantities of material. This modified Phase 3B program has two specific aims: 1) successful completion of H800, that together with L500 will generate a field of 30.53 T and a 1H frequency of 1.3 GHz; 2) development, continued from Phase 3A, of field-shimming techniques to convert, after completion of this modified Phase 3B program, the 30.53-T L500/H800 magnet to a high-resolution 1.3 GHz NMR magnet (1.3G) capable of producing 1-Hz linewidths. These new field shimming techniques are essential for NMR magnets that rely on HTS tape conductor. As discussed further in 3. Research & Strategy, to achieve Aim 1 in the most efficient, and affordable manner, we are applying innovative design concepts to build HTS DP coils: no-insulation winding technique and inside-notch DP coils. To ensure the highest possible probability to achieve Aim 2 we have initiated in Phase 3A, and to continue in this modified Phase 3B program, development of two innovative field shimming techniques: persistent-mode HTS shims and “shaking-field” magnet. As also discussed in 3. Research & Strategy, an L500/H800 combination is considerably less expensive than a combination of a <4.2-K operated 900-MHz LTS magnet (L900) and a 400- MHz HTS insert (H400)—this will become a reality when the HTS insert becomes standard for a >1-GHz NMR magnet. Moreover, because the footprint of a >1-GHz LTS/HTS magnet is essentially determined by that of the LTS component, space-wise our L500/H800 combination is more efficient, and certainly desirable, than an L900/H400 combination. Modified