Center for Complex Data to Knowledge in Drug Abuse and HIV Behavioral Science

 描述(由申请人提供)：新的技术和方法，如用智能手机和审查员收集数据，正在产生丰富的数据集，可用于创建新一代药物滥用和艾滋病毒预防和服务干预措施。然而，统计分析方法--研究人员用来打开包含在行为数据中的科学知识之门的钥匙--已经跟不上现代数据集的复杂性和当今行为研究人员提出的问题的复杂性。拟议的药物滥用和艾滋病毒行为科学知识复杂数据中心(CD2K中心)的重点是开发和传播创新的统计方法，这些方法对于解开复杂行为数据中包含的知识并将其应用于打击药物滥用和艾滋病毒的斗争至关重要。我们提出了一套三个令人兴奋的、主题集成的研究项目，每个项目都开发了分析复杂数据的创新方法。我们还提出了三个核心来支持和加强研究，广泛传播创新方法，并吸引和指导行为药物滥用和艾滋病毒方法学领域的新手。CD2K中心的总体具体目标是：(A)开发分析复杂数据的创新方法，为药物滥用和艾滋病毒预防提供复杂、强大和有效的行为干预；增加与药物滥用和艾滋病毒相关行为的病因学知识；以及指导更有效地提供药物滥用和艾滋病毒干预服务。开发的方法将有助于在复杂数据的基础上获得最高质量的经验证据。(B)将目标A中开发的创新方法应用于现有的药物使用和艾滋病毒数据集，以便在预防药物滥用和艾滋病毒、药物滥用和艾滋病毒病原学以及提供药物滥用和艾滋病毒干预服务等领域推进行为科学。我们将与充满活力的药物滥用和艾滋病毒科学家网络合作，利用他们收集的数据进行实证研究，并在同行评议的渠道上公布结果。(C)将CD2K中心开发的创新方法交到世界各地的药物滥用和艾滋病毒科学家手中，作为国家资源。(D)作为国家资源，培养当代和下一代致力于研究药物滥用和艾滋病毒预防、流行病学和服务提供的定量方法学家。总之，CD2K中心将很快成为一个充满活力和新鲜的国家资源，为复杂数据提供创新的统计方法。这些尖端方法将使科学家能够首次解决一系列令人兴奋的研究问题，这些问题涉及药物滥用和艾滋病毒背后的行为动力学和因素，并最终为新一代高效干预措施铺平道路，这些干预措施将降低药物滥用和艾滋病毒感染的流行率和发生率。

 DESCRIPTION (provided by applicant): New technologies and approaches, such as data collection with smartphones and censors, are producing data sets that are rich with information that could be used to create a new generation of interventions for drug abuse and HIV prevention and services. However, statistical analysis methods, the keys investigators use to open the door to the scientific knowledge contained in behavioral data, have not kept up with the complexity of modern data sets and the sophistication of the questions posed by today's behavioral researchers. The focus of the proposed Center for Complex Data to Knowledge in Drug Abuse and HIV Behavioral Science (CD2K Center) is development and dissemination of the innovative statistical methods that are essential to unlock the knowledge contained in complex behavioral data and apply it in the fight against drug abuse and HIV. We propose a set of three exciting, thematically integrated research projects, each developing innovative methods for analysis of complex data. We also propose three cores to support and enhance the research, disseminate the innovative methods broadly, and attract and mentor newcomers to the field of behavioral drug abuse and HIV methodology. The overall Specific Aims of the CD2K Center are (A) To develop innovative methods for analysis of complex data that will be tailor-made to inform sophisticated, powerful, and efficient behavioral interventions for drug abuse and HIV prevention; increase knowledge about the etiology of behaviors related to drug abuse and HIV; and guide more effective delivery of drug abuse and HIV intervention services. The methods developed will facilitate the acquisition of highest quality empirical evidence based on complex data. (B) To apply the innovative methods developed in Aim A in existing drug use and HIV data sets, for the purpose of advancing behavioral science in the areas of prevention of drug abuse and HIV, drug abuse and HIV etiology, and delivery of drug abuse and HIV intervention services. We will work with a vibrant network of drug abuse and HIV scientists on empirical studies using the data they have collected and publish the results in peer-reviewed outlets. (C) To serve as a national resource by placing the innovative methods developed in the CD2K Center in the hands of drug abuse and HIV scientists worldwide. (D) To serve as a national resource by nurturing the current and next generations of quantitative methodologists devoted to the study of drug abuse and HIV prevention, epidemiology, and services delivery. In sum, the CD2K Center will quickly become an energetic and fresh national resource for innovative statistical methods for complex data. These cutting- edge methods will enable scientists to address, for the first time, a host of exciting research questions about the behavioral dynamics and factors that underlie drug abuse and HIV, and ultimately pave the way for a new generation of highly effective interventions that will reduce the prevalence and incidence of drug abuse and HIV infection.