Phthalate and stressful life event exposures and pregnancy outcomes: The role of oxidative stress

该项目很好地符合NIEHS的战略目标：1)包括调查综合环境暴露如何影响疾病的发病机制；2)提高对共同生物途径的了解，在这种情况下，氧化应激是这些暴露影响的基础；3)调查怀孕期间的暴露是如何与儿童早期生命发育有关的一个关键的易感窗口。该项目是今年启动的，因此到目前为止还没有任何出版物。然而，自从1月份开始我在NIEHS的职位以来，我在数据收集方面已经迈出了几个实质性的步骤。首先，在自由基代谢组(免疫、炎症和疾病分部)的研究人员的帮助下，我已经建立了一个实验室，该实验室将用于尿样中的氧化应激分析，唯一来源的合理性尚待确定。其次，我与合作者Thomas McElrath博士一起优化了一个医疗记录摘要表格，以从潮汐参与者那里获得关于特定分娩结果的额外信息。第三，我已经得到了IRB的批准，修改后从西奈山的伊坎医学院提取了这些数据。我现在正与潮汐研究小组在四个单独的研究地点合作，以获得那里的修改的批准。最后，我获得了NIEHS的豁免，这样我就可以利用从研究中收集的数据。在接下来的一年里，我预计将收到有关妊娠晚期尿氧化应激生物标志物、病历数据和尿邻苯二甲酸盐代谢物的数据，并将开始分析数据并发布这项研究的结果。

This project aligns well with the strategic goals of NIEHS by: 1) Including investigation of how combined environmental exposures impact disease pathogenesis; 2) Improving understanding of a shared biological pathway, in this case oxidative stress, underlying the impact of these exposures; and 3) Investigating how exposures during pregnancya critical window of susceptibilityrelate to the early life development of the child. This project was initiated this year, and thus does not have any publications to date. However, since beginning my position at NIEHS in January, I have made several substantial steps toward data collection. First, with input from investigators in the Free Radical Metabolism Group (Immunity, Inflammation, and Disease Branch), I have established the laboratory that will be utilized for oxidative stress analyses in urine samples and have a sole source justification pending. Second, I optimized a medical record abstraction form with collaborator Dr. Thomas McElrath to obtain additional information from TIDES participants on specific delivery outcomes. Third, I have received IRB approval for a modification to abstract this data from the Icahn School of Medicine at Mount Sinai. I am now working with the TIDES study team at the four individual study sites to obtain approval for the modifications there as well. Lastly, I have obtained an exemption from NIEHS so that I may utilize the data collected from the study. During the next year I anticipate receiving data on urinary oxidative stress biomarkers, medical record data, and urinary phthalate metabolites from the third trimester of pregnancy, and will begin analyzing data and publishing the results from this study.