Data & Information Tech Core - Athey

项目摘要(见说明)：密歇根区域综合代谢组学资源核心(MRC2)的数据和信息技术核心将为从定向代谢组学数据中分析光谱数据提供专业知识，并在分析高通量、非靶向代谢物分析方面提供重要的工具和研究，使用更广泛的代谢组分析。通过提供近748种真实代谢物的资料库以及近500个血浆样本中的已知未知物资料库，非靶向代谢组学资料中的化合物鉴定将得到加强，这些化合物的光谱特征已通过反相和亲水作用层析(HILIC)飞行时间(TOF)确定。核心还将在数据分析之前提供数据标准化程序。核心还将负责数据管理、注释和存储，并将与数据储存库和协调中心(DRCC)合作，提供在核心中进行的实验的原始和标准化数据。数据和信息技术核心将与密歇根大学的IT团队合作，对MRC2的信息技术基础设施进行维护、故障排除和升级。

PROJECT SUMMARY (See Instructions): The Data and Information Technology Core of the Michigan Regional Comprehensive Metabolomics Resource Core (MRC2) will provide expertise for the analysis of spectral data from directed metabolomics data and provide important tools and research in the analysis of high-throughput, untargeted metabolite analysis used wider profiling of the metabolome. The identification of compounds in the untargeted metabolomics profile will be enhanced by the availability of a library of nearly 748 authentic metabolites whose spectral features have been determined on reverse phase and hydrophilic interaction chromatography (HILIC) time of flight (TOF) as well as a library of known unknowns' identified in nearly 500 plasma samples. The Core will also provide procedures for data normalization prior to data analysis. The Core also will be responsible for data curation, annotation and storage and will work with the Data Repository and Coordinating Center (DRCC) to provide raw and normalized of experiments performed in the core. The Data and Information Technology Core will work with IT teams within the University of Michigan to maintain, troubleshoot and upgrade the Information Technology infrastructure of the MRC2.