Pilot and Exploratory Science Core

试点和探索性研究的核心--摘要 在伊斯兰会议组织总体任务范围内，试点和探索性研究核心(PESC)旨在 为创新的先导研究项目提供催化支持-种子资金、核心支持和指导 生成关于FPT行动机制的数据，以促进更明确的机制研究、可行性 指导疗效试验、假设生成或概念验证探索性研究和回溯性研究的数据 分析为计划生育干预提供信息的现有流行病学数据。 该委员会的宗旨是： 目标1.为早期创新和跨学科研究建立转化渠道，方法是提供 资金和基础设施： ·生成概念验证临床前数据，以加快FPTS的开发。 ·目标识别或建立假设的机制研究，FPT通过这些机制发挥作用 骨骼肌和身体功能(例如，PES-1)。 ·在人类受试者或动物模型中进行翻译干预或研究方案的试点测试 安全性、可行性或最佳时间进程或剂量的确定(例如，PES-2、PES-3)。 目标2：在PESC调查人员和OAIC核心资源之间建立联系。 目标3：每两年监测一次，并指导PESC研究人员的研究项目取得成功。 目标4.将试点和探索性项目转化为高质量的同行评议出版物，赠款 应用程序和知识产权/专利，只要有可能。 我们从11个应用程序池中选择了3项针对PESC支持的创新研究，因为这些 这些研究与伊斯兰会议组织促进技术合作伙伴关系发展的使命相一致： PES-1将表征运动中的microRNAs，并作为老年人合成代谢反应的生物标记物。 PES-2将评估家庭锻炼计划是否可以改善患者的功能结果 接受经导管主动脉瓣置换术。 PES-3将确定经颅脑刺激是否能改善老年人的身体功能。 在最初的5年资助期间，波士顿OAIC支持了11个PES项目，时间从1年到2.5年不等。75万澳元 OAIC的投资产生了1795万美元的外部资金，两项专利和75份同行评议的出版物 包括《衰老细胞》(Guo 2013，Jasuja 2014)中的论文，一本关于医学中的翻译生物学的书(蒙大诺 2014年，Elsevier出版社)，PNAS(Hettmer，2011年)，《循环》(杰斐逊，2010年)和NEJM(巴萨里亚，2012年)。 PESC将由两位拥有互补专业知识和指导技能的科学家领导；蒙蒂·蒙塔诺博士， 一位在肌肉和衰老方面有专长的翻译科学家；以及道格拉斯·基尔博士，一位临床研究员， 肌肉骨骼衰老和促进功能疗法的干预试验方面的专业知识。

PILOT AND EXPLORATORY STUDIES CORE - SUMMARY Within the context of the OAIC's overall mission, the Pilot and Exploratory Studies Core (PESC) aims to provide catalytic support – seed funding, core support, and mentorship - for innovative pilot research projects that generate data on the mechanisms of FPT action to facilitate more definitive mechanistic studies, feasibility data to guide efficacy trials, hypothesis generating or proof-of-concept exploratory studies and retrospective analysis of existing epidemiologic data that inform FPT interventions. The aims of this PESC are: Aim 1. To build a translational pipeline for early stage innovative and interdisciplinary research by providing funding and infrastructure for: • Generation of proof-of-concept preclinical data to expedite the development of FPTs. • Mechanistic studies for target identification or hypotheses building by which FPTs exert their effects on skeletal muscle and physical function (e.g., PES-1). • Pilot testing of translational interventions or research protocols in human subjects or animal models for safety, feasibility, or determination of optimal time course or dosage (e.g., PES-2, PES-3). Aim 2: To build connectivity between PESC investigators and OAIC core resources. Aim 3: To monitor biannually and guide success of research projects by PESC investigators. Aim 4. To catalyze pilot and exploratory projects into high quality peer-reviewed publications, grant applications, and intellectual property/ patents, whenever possible. We selected 3 innovative studies for PESC support, from among a pool of 11 applications, because these studies are well aligned with the OAIC's mission of promoting the development of FPTs: PES-1 will characterize microRNAs in exercise and as biomarkers for anabolic response in aged adults. PES-2 will evaluate whether a home-based exercise program can improve functional outcomes in patients undergoing trans-catheter aortic valve replacement. PES-3 willl determine if transcranial brain stimulation can improve physical function in older adults. During its initial 5 years of funding, Boston OAIC supported 11 PES projects from 1 to 2.5 years. A $750,000 OAIC investment yielded $17.95 million in extramural funding, two patents, and 75 peer reviewed publications including papers in Aging Cell (Guo 2013, Jasuja 2014), a book on translational biology in medicine (Montano 2014, Elsevier Publishers), PNAS (Hettmer 2011), Circulation (Jefferson 2010) and NEJM (Basaria 2012). This PESC will be led by two scientists with complementary expertise and mentoring skills; Dr. Monty Montano, a translational scientist with expertise in muscle and aging; and, Dr. Douglas Kiel, a clinical investigator with expertise in musculoskeletal decline with aging and intervention trials of function promoting therapies.