Pharmacogenetic investigations of glutathione transferases

众所周知，谷胱甘肽转移酶家族的成员负责一系列化合物的代谢和解毒，包括治疗药物和致癌化学物质。个体谷胱甘肽转移酶的遗传变异会改变他们对药物治疗的反应或对癌症的敏感性。这项研究将研究(1)改变谷胱甘肽转移酶产生的遗传机制，(2)一类新的谷胱甘肽转移酶的特征，以及(3)谷胱甘肽转移酶A4在预防动脉粥样硬化和帕金森病等疾病中的作用。

Members of the family of enzymes known as glutathione transferases are known to be responsible for the metabolism and detoxification of a wide range of compounds including therapeutic drugs and cancer causing chemicals. Genetic variation in an individual's compliment of glutathione transferases can alter their response to drug treatment or their susceptibility to cancer. This study will investigate (1)the genetic mechanisms that alter the production of glutathione transferases, (2) the characteristics of a new class of glutathione transferases and (3) the role of glutathione transferase A4 in protecting against disorders such as atherosclerosis and Parkinson's disease.