Prospective clinical research of radiation response to high-dose radiotherapy in lung tumours and surrounding normal tissue using functional imaging biomarker assessments

放射疗法是一种潜在的肺癌治疗方法。为了改善结果，现代研究工作集中在放射治疗剂量递增上。然而，剂量递增的主要限制是对肺的相关毒性。目前，肺毒性的机制还不完全清楚。本研究将通过使用最先进的扫描技术来研究接受高剂量放射治疗的患者的放射反应生物标志物。

Radiotherapy is a potentially curative treatment for cancers of the lung. To improve outcomes, modern research efforts have focussed on radiotherapy dose escalation. However a major limitation to dose escalation is the associated toxicity to the lung. At present, the mechanisms of lung toxicity are incompletely understood. This research will investigate biomarkers of radiation response in patients receiving high-dose radiotherapy to the lung by using state-of-the-art scanning techniques.