Protein kinases regulate salt reabsorption in the kidney

这项建议旨在确定肾脏如何感知体内的盐含量并监测血压。这对高血压、肾衰竭和心力衰竭等疾病至关重要，因为这些疾病中的盐被不适当地保留。我们认为肾脏使用被称为激酶的蛋白质，这些蛋白质被肾脏中的盐激活。当它太低时，它们会检测到这一点，并导致肾脏吸收更多的盐来纠正不足。他们能够做到这一点的方式对人类心脏和肾脏疾病以及一般生物学具有深远的影响。

This proposal is designed to determine how the kidney senses the level of salt in the body and monitors blood pressure. This is critical for diseases such as hypertension, kidney and heart failure, where salt is retained inappropriately. We propose that the kidney uses proteins called kinases that are activated by salt in the kidney. When it is too low, they detect this and cause the kidney to absorb more salt to correct the deficiency. The way that they are able to do this has profound implications for human heart and kidney disease, and biology in general.