Alternative targets for treating cancer

癌细胞通常是通过逃避细胞死亡来维持的。因此，一种有希望的方法来开发新的癌症治疗方法，旨在恢复他们自杀细胞的能力。在这方面，与Bcl-2相关的蛋白质是有吸引力的靶标，因为它们是细胞死亡的显著障碍。该项目旨在揭示Bcl2相关基因Mcl-1是如何被调控的，并探索支撑这些过程的机制如何在其所持续的癌症(黑色素瘤、白血病)中被靶向。

Cancer cells are often sustained by evading cell death. Thus, a promising approach to develop new cancer treatments aims to restore their ability to commit cell suicide. Proteins related to Bcl-2 are, in this regard, attractive targets because they are prominent barriers to cell death. This project seeks to uncover how a Bcl-2 relative, Mcl-1, is regulated, and to explore how the mechanisms that underpin these processes can be targeted in cancers (melanomas, leukemias) that it sustains.