An investigation into chromatin dynamics in host-pathogen interactions and fungal virulence

真菌感染是一个重大的健康负担，造成的生命损失与疟疾不相上下。只有少数抗真菌治疗是可用的，死亡率仍然很高（30%或更多）。本项目旨在利用分子生物学方法和动物感染模型，对人类主要真菌病原体白色念珠菌中一类新的有前途的抗真菌药物靶点进行表征。这些结果将为未来的抗真菌药物发现提供知识基础。

Fungal infections represent a major health burden, with loss of lives that parallels malaria. Only a handful of antifungal therapeutics is available, and mortality remains very high (30% or more). By using molecular biology approaches and animal infection models, this project aims to characterize a new class of promising antifungal drug targets in the major human fungal pathogen Candida albicans. The outcomes will provide the knowledge foundation for future antifungal drug discovery.