The anti-inflammatory role of collagen IV in asthma

我们发现哮喘患者的肺部缺少一种蛋白质，tumstatin。我们现在有令人兴奋的数据显示，这是第一次，吐司他汀可以停止炎症。如果塔司他汀是正常情况下限制肺部炎症的系统的一部分，那么它在哮喘中的缺失可能是至关重要的。在这项资助中，我们将发现塔司他汀是如何阻断炎症的，以及为什么它在哮喘中不存在。我们的研究将提供有关吐司他汀在气道中的作用的重要信息。

We have discovered that a protein, tumstatin, is missing from the lungs of people with asthma. We now have exciting data showing, for the first time, that tumstatin can stop inflammation. If tumstatin is part of the system that normally limits inflammation in the lungs its absence in asthma may be critical. In this grant we will discover how tumstatin works to block inflammation and why it is absent in asthma. Our studies will provide vital information about the role of tumstatin in the airways.