The interaction between the host and pathogen genetics in susceptibility to pulmonary tuberculosis

感染导致结核病(TB)的细菌的人有不同的临床命运。一些人在潜伏感染中保持良好，一些人患上肺部疾病并存活下来，另一些人死亡。我们正在通过识别两者的遗传变异来研究人类宿主和致病细菌之间的相互作用。这将使我们能够确定在防御这种疾病方面什么是重要的。对不同结核病过程的了解对于未来合理设计新的结核病疫苗和治疗方法至关重要。

People infected with the bacteria causing tuberculosis (TB) have different clinical fates. Some people remain well with dormant infections, some get lung disease and survive, others die. We are investigating the interplay between the human host and the bacteria causing disease by identifying genetic variants in both. This will enable us to determine what is important in the defence against this disease. Knowledge of the different TB disease processes is critical for future rational design of new TB vaccines and treatments.