The preferential release of young insulin secretory granules.

本研究的目的是探讨2型糖尿病患者葡萄糖诱导的胰岛素分泌减少的原因。在胰腺β细胞中，胰岛素被包装并储存在分泌颗粒（SG）中。在刺激时，这些SG将胰岛素输送到血流中。已知胰岛素SG存在于两个功能不同的库中;并且一个库在刺激时优先分泌。细胞如何区分两个SG池尚不清楚，我们将在本项目中解决这个问题。

The aim of this study is to investigate the cause of reduced glucose induced insulin secretion in type 2 diabetes. In pancreatic beta-cells, insulin is packaged and stored in secretory granules (SGs). Upon stimulation, these SGs deliver insulin to the bloodstream. It is known that insulin SGs exist in two functionally distinct pools; and one pool is preferentially secreted upon stimulation. How a cell can differentiate the two SG pools is unclear, and we will address this issue in this project.