Astroglial remodelling of the interhemispheric midline is regulated by deleted in colorectal cancer (DCC) signalling and is required for corpus callosum formation

大脑半球之间的信息整合是通过一束被称为胼胝体的连接神经纤维完成的。患有DCC基因突变的人会出现镜像运动障碍，有些人会出现严重的脑缺陷，胼胝体无法形成，但目前我们还不了解该基因的功能。在这项研究中，我们将探讨DCC如何在早期大脑发育中调节胼胝体的形成和镜像运动障碍。

The integration of information between the brain hemispheres occurs via a large bundle of connecting nerve fibres called the corpus callosum. People with a genetic mutation in DCC display mirror movement disorder and some have a severe brain defect where the corpus callosum fails to form, but at present we don’t understand the function of this gene. In this study we will investigate how DCC functions in early brain development to regulate corpus callosum formation and mirror movement disorder.