High-pressure homogenizer for the creation of liposomes and amulsions

从研究工具和仪器赠款中购买的高压均质器/挤出机系统将支持达尔豪西大学三名研究人员的活动，他们在制药，海洋提取物和食品安全领域工作。 该设备可用于生产具有上级特性的脂质体和乳液以及用于细胞破碎。 将得到支持的药物研究涉及微囊化脂质体药物颗粒的生产，目的是提高肺部给药的稳定性和控释性能。 此外，脂质体的制备对于海洋阳离子抗菌肽及其对食品相关菌的作用研究具有重要意义。 高压均质器还将用于从具有分解麻痹性贝类毒素能力的细菌中提取酶。 它还将用于研究将化学修饰的抗菌肽（从鲱鱼鱼糜中提取）掺入食品中的潜力。

The high pressure homogenizer/extruder system to be purchased from this Research Tools and Instruments grant will support the activities of three researchers at Dalhousie University, working in areas relating to pharmaceuticals, marine extracts and food safety.  This equipment can be used to produce liposomes and emulsions with superior properties and for cell disruption.   The pharmaceutical research that will be supported involves the production of microencapsulated liposomal drug particles with the aim of improving stability and controlled-release properties for pulmonary delivery.  In addition, liposomal preparation will be important for the study of marine cationic antimicrobial peptides and their effects on food-related bacteria.  The high pressure homogenizer will also be used to extract enzymes from bacteria that have the ability to break down paralytic shellfish toxins.  It will also be used to study the potential for incorporating a chemically-modified antimicrobial peptide (extracted from herring milt) into food.