Blocking IL-6 trans-signaling: a therapeutic strategy to prevent metabolic disease
Blocking IL-6 trans-signaling: a therapeutic strategy to prevent metabolic disease
批准号:
nhmrc : 1041760
负责人:
Prof Mark Febbraio
金额:
$36.05万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31
中文摘要
众所周知,阻断特异性免疫细胞即巨噬细胞向肥胖患者脂肪组织的募集将改善其代谢健康。然而,迄今为止,一种可行的药物仍然难以捉摸。我们已经开发了一种叫做sgp130Fc的药物。该项目将在临床前测试该药物的有效性。
英文摘要
It is well known that blocking the recruitment of specific immune cells namely macrophages to adipose tissue of obese patients will improve their metabolic health. However, to date, a viable drug to do this has remained elusive. We have developed such a drug called sgp130Fc. This project will test the effectiveness of this drug in a pre-clinical setting.
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Towards a better understanding of the health benefits of physical activity: designing exercise mimetic for the treatment of disease
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Discovery of novel myokines by innovative proteomic analyses
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批准号:DP130103573
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负责人:Prof Mark Febbraio
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依托单位:
Reapplication with Promotion
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批准号:nhmrc : 1021168
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项目类别:Research Fellowships
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财政年份:2012
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依托单位:
An essential role for skeletal muscle FoxO1 in protecting against obesity-induced insulin resistance
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负责人:Prof Mark Febbraio
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依托单位:
Research Fellowship - Grant ID:445302
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批准号:nhmrc : 445302
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负责人:Prof Mark Febbraio
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依托单位:
Autophagic vacuole formation in mammalian skeletal muscle; role of FOXO proteins.
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批准号:DP0770546
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项目类别:Discovery Projects
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资助金额:$15.72万
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财政年份:2007
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负责人:Prof Mark Febbraio
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依托单位:
Role of FoxO proteins in the regulation of skeletal muscle anabolism, catabolism and insulin sensitivity
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批准号:nhmrc : 445300
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项目类别:NHMRC Project Grants
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资助金额:$33.57万
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财政年份:2007
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负责人:Prof Mark Febbraio
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依托单位:
Ciliary Neurotrophic Factor: a novel theraputic agent for the prevention of muscle insulin resistance
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批准号:nhmrc : 392206
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项目类别:NHMRC Project Grants
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资助金额:$40.19万
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负责人:Prof Mark Febbraio
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依托单位:
Regulatory mechanisms in skeletal muscle lipid hydrolysis
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依托单位:
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批准号:nhmrc : 292902
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项目类别:NHMRC Research Fellowships
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资助金额:$24.87万
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负责人:Prof Mark Febbraio
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依托单位:
Biological Role of Contraction-Induced Heat Shock Protein Expression
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批准号:DP0209570
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财政年份:2002
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负责人:Prof Mark Febbraio
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依托单位:
国内基金
海外基金
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