Bone marrow macrophages: “Resident Evil” in the establishment and progression of multiple myeloma

多发性骨髓瘤（MM）是一种发生在骨髓（BM）内的癌症。迄今为止，骨髓基质中哪些细胞是支持MM生长所必需的仍是未知的。我们的初步数据表明，表达CD169和CX3CR1的BM驻留巨噬细胞对MM生长至关重要。利用创新和优雅的MM动物模型，我们将定义这些巨噬细胞在MM生长中的作用，并确定巨噬细胞靶向治疗是否可以延缓复发疾病中MM的生长。

Multiple myeloma (MM) is a cancer that develops within the bone marrow (BM). To date, which cells of the BM stroma are required for the support of MM growth remains unknown. Our preliminary data suggest BM resident macrophages, expressing CD169 and CX3CR1, are essential for MM growth. Using innovative and elegant animal models of MM, we will define the role of these macrophages in MM growth and determine if macrophage-targeted therapies can delay MM growth in the relapsed disease setting.