Cancer Genetics, epigenetics and targeted therapies

我的目标是更深入地了解血癌是如何发生的，以及我们最终应该如何治疗这些疾病的患者。我将找出导致血癌发展的基因缺陷，这些基因缺陷是如何通过所谓的“表观遗传”变化去调节基因表达，从而使这些异常的血细胞生长和存活的。我将在实验模型中测试干扰致癌表观遗传和信号通路的小分子的活性。

I aim to gain greater insight into how blood cancers arise and how we should ultimately treat patients with these diseases. I will identify the genetic defects that underpin the development of blood cancers, how these genetic defects de-regulate gene expression through so-called “epigenetic” changes to allow these abnormal blood cells grow and survive. I will test the activity of small molecules that interfere with the cancer-causing epigenetic and signaling pathways in experimental models.