Cartilage Biology in Health and Disease
Cartilage Biology in Health and Disease
批准号:
nhmrc : 1002871
负责人:
Prof Amanda Fosang
金额:
$48.52万
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2015-12-31
中文摘要
我是一名软骨生物化学家,研究(1)正常骨骼生长发育中的软骨重建,以及(2)关节炎疾病中破坏软骨的分子事件。我的研究重点是定义软骨结构的分子,以及降解和重塑软骨结构的酶。我们的分析包括使用试管中的分子,具有抗降解软骨的转基因小鼠,以及关节炎患者的滑液样本。
英文摘要
I am a cartilage biochemist investigating (1) cartilage remodelling in normal skeletal growth & development and (2) the molecular events that destroy cartilage in arthritic diseases. My research focuses on the molecules that define cartilage structure, and the enzymes that degrade and remodel it. Our analyses include work with molecules in test tubes, genetically modified mice with degradation-resistant cartilage, and synovial fluid samples from arthritis patients.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Vanin-3 signalling in osteoarthritis
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批准号:nhmrc : GNT1060576
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项目类别:Project Grants
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资助金额:$63.04万
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财政年份:2014
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负责人:Prof Amanda Fosang
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依托单位:
Vanin-3 signalling in osteoarthritis
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批准号:nhmrc : 1060576
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项目类别:Project Grants
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资助金额:$43.79万
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财政年份:2014
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负责人:Prof Amanda Fosang
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依托单位:
Signalling through a bioactive aggrecan fragment: what is the mechanism?
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批准号:nhmrc : 1060222
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项目类别:Project Grants
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资助金额:$28.76万
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财政年份:2014
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负责人:Prof Amanda Fosang
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依托单位:
Angiogenic defects in mutant growth plate cartilage reveal new modulators of vascular invasion
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批准号:DP130104083
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项目类别:Discovery Projects
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资助金额:$25.15万
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财政年份:2013
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负责人:Prof Amanda Fosang
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依托单位:
Chondrocyte hypertrophy in development and disease
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批准号:nhmrc : 607385
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项目类别:NHMRC Project Grants
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资助金额:$24.01万
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财政年份:2010
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负责人:Prof Amanda Fosang
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依托单位:
Regulation of ADAMTS-5 activity by keratan sulphate-binding exosites
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批准号:nhmrc : 454435
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项目类别:NHMRC Project Grants
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资助金额:$14.23万
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财政年份:2007
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负责人:Prof Amanda Fosang
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依托单位:
Molecular mechanisms of cartilage degeneration in osteoarthritis
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批准号:nhmrc : 384414
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项目类别:NHMRC Project Grants
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资助金额:$30.51万
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财政年份:2006
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负责人:Prof Amanda Fosang
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依托单位:
Research Fellowship - Grant ID:400057
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批准号:nhmrc : 400057
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项目类别:NHMRC Research Fellowships
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资助金额:$44.31万
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财政年份:2006
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负责人:Prof Amanda Fosang
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依托单位:
How important is collagen destruction in arthritis? A study with collagenase-resistant knockin mice
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批准号:nhmrc : 400056
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项目类别:NHMRC Project Grants
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资助金额:$35.32万
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财政年份:2006
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负责人:Prof Amanda Fosang
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依托单位:
Role of proteoglycans in fetal lung maturation
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批准号:nhmrc : 237103
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项目类别:NHMRC Project Grants
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资助金额:$17.02万
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财政年份:2003
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负责人:Prof Amanda Fosang
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依托单位:
Cartilage destruction in arthritis: mechanism of aggrecanase & matrix metalloproteinase action in vivo & in vitro
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批准号:nhmrc : 170207
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项目类别:NHMRC Research Fellowships
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资助金额:$31.58万
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财政年份:2001
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负责人:Prof Amanda Fosang
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依托单位:
Cartilage destruction in arthritis: Mechanism of aggrecanase and matrix metalloproteinase action in vivo and in vitro
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批准号:nhmrc : 145619
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项目类别:NHMRC Project Grants
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资助金额:$46.89万
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财政年份:2001
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负责人:Prof Amanda Fosang
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依托单位:
Analysis of aggrecan metabolism by site-directed mutagenesis and neo-epitope technology
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批准号:nhmrc : 970316
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项目类别:NHMRC Project Grants
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资助金额:$36.45万
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财政年份:1997
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负责人:Prof Amanda Fosang
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依托单位:
国内基金
海外基金
Journal of Integrative Plant Biology
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批准号:31024801
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项目类别:专项基金项目
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资助金额:24.0万元
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批准年份:2010
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负责人:贺萍
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依托单位: