CCRE in Clinical Science in Diabetes

糖尿病影响着100多万澳大利亚人，在澳大利亚和全世界都是一个日益严重的健康问题。糖尿病会损害小血管，伤害肾脏和眼睛，而大血管会导致心脏病发作、中风和截肢。领导该卓越临床研究中心（CCRE）的研究团队在糖尿病研究方面拥有丰富的经验，包括医院和社区环境中的糖尿病管理专家。在眼病和糖尿病的饮食管理方面有专门的专业知识。研究小组将对糖尿病进行研究，包括通常在儿童时期开始的1型糖尿病和通常影响中年或老年人的2型糖尿病，尽管随着人口变得越来越肥胖，越来越多地发生在年轻人身上。我们将重点关注并发症，这两种糖尿病都很常见，寻找早期发现和预防的方法。我们的研究将涉及多达10,000名糖尿病患者，有时随访超过5年或更长时间。澳大利亚土著群体将被纳入研究范围，因为他们患糖尿病及其并发症的比例很高。我们还将研究如何让2型糖尿病患者更多地参与改善他们的疾病管理。该研究项目的一个令人兴奋的部分将涉及对产生胰岛素的人类胰岛细胞进行移植的患者。虽然这种治疗方法只适用于少数患者，但它是未来使用人类细胞治疗的重要进展。该中心将非常注重招募和培训下一代医生和其他参与糖尿病研究的临床医生，包括护士、营养师和验光师。

Diabetes affects over one million Australians and is an increasing health problem in Australia and worldwide. Diabetes can damage small blood vessels, harming the kidneys and eyes and large blood vessels leading to heart attack, stroke and leg amputation. The research team leading this Centre for Clinical Research Excellence (CCRE) has wide experience in diabetes research and includes experts in diabetes management in hospitals and in the community setting of general practice. There is special expertise in eye disease and in dietary management of diabetes. The research team will conduct research into diabetes, both type 1 diabetes, which usual starts in childhood, and type 2 diabetes that generally affects middle aged or older people, although increasingly is occurring in younger adults as the population becomes more obese. We will focus on the complications, which are common to both types of diabetes, looking for ways to detect them early and prevent them. Our studies will involve groups of up to 10,000 people with diabetes, sometimes followed over 5 or more years. Indigenous Australian groups will be included in the studies as they have a high rates of diabetes and its complications. We will also study ways in which people with type 2 diabetes can be more involved in improving the management of their illness. An exciting part of the study program will involve patients having transplants of insulin producing human islet cells. Although this treatment will be available for only a few patients, it is an important advance towards future treatments using human cells. The CCRE will have a very strong focus on recruiting and training the next generation of doctors and other clinicians involved in diabetes research, including nurses, dietitians and optometrists.