Cellular regulation of receptor signalling and cytokine responses

细胞表面受体和信号通路引发细胞因子或化学信使的释放，以控制炎症，这是身体对感染或危险的反应。我们发现了一种新的信号通路，可以关闭炎症并帮助预防炎症性疾病。我们的研究现在将定义这一途径的分子细节，并展示靶向这一途径的新药物和现有药物如何最佳地用于治疗炎症和癌症。

Cell surface receptors and signalling pathways elicit the release of cytokines, or chemical messengers, to control inflammation, which is the body’s response to infection or danger. We have discovered a new signalling pathway that can turn off inflammation and help prevent inflammatory disease. Our studies will now define the molecular details of this pathway and show how new and existing drugs targeting this pathway can be optimally used to treat inflammation and cancer.