A high-resolution imaging modality for electrical impedance magnetoacoustic tomography with magnetic induction

关于生物组织内的电阻抗分布的信息对于许多目的是有用的，例如癌症检测和监测生理功能。然而，没有高空间分辨率成像模式的电阻抗已开发用于临床应用。申请人最近已经对用于电阻抗的新的高分辨率成像模态进行了一些理论和实验研究：具有磁感应的磁声层析成像（MAT-MI）。MAT-MI结合了电阻抗断层成像的良好对比度和超声成像的良好空间分辨率。在初步研究中，申请人已经推导出MAT-MI的正问题和逆问题的公式，并获得了生物组织的定性MAT-MI图像。在拟议的研究中，申请人计划证明可以从生物组织的数值模拟数据和实验数据定量重建电阻抗的高空间分辨率图像。预计拟议的调查将开发一个高空间分辨率的电阻抗成像模式的医疗诊断和治疗。

Information about electrical impedance distribution inside biological tissues is useful for many purposes, such as cancer detection and monitoring physiological functions. However, no high-spatial-resolution imaging modality for electrical impedance has been developed for clinical applications. The applicant recently has performed some theoretical and experimental investigations on a novel high-resolution imaging modality for electrical impedance: magnetoacoustic tomography with magnetic induction (MAT-MI). MAT-MI combines the good contrast of electrical impedance tomography with the good spatial resolution of sonography. In the preliminary investigations, the applicant has derived the formulas for both the forward and inverse problems of MAT-MI and obtained qualitative MAT-MI images of biological tissues. In the proposed study, the applicant plans to demonstrate that high-spatial-resolution images of electrical impedance can be reconstructed quantitatively from both numerically-simulated data and experimental data on biological tissues. It is anticipated that the proposed investigation will develop a high-spatial-resolution imaging modality of electrical impedance for medical diagnosis and therapy.