Characterising the pro-inflammatory role of IL-36?/IL-36R in pathogen-induced exacerbations of asthma and COPD

肺部感染会导致哮喘和慢性阻塞性肺病患者病情恶化，这些疾病很难治疗，可能危及生命。我们发现，细胞因子途径，IL-36？/IL-36R，与宿主对导致这些患者病情恶化的细菌和病毒感染的反应有关。我们的研究将为IL-36？/IL-36R在感染、疾病恶化中的作用提供新的见解，并确定阻断这一途径的治疗益处。

Lung infections cause exacerbations in patients with asthma and COPD and these are difficult to treat and can be life-threatening. We have discovered that the cytokine pathway, IL-36?/IL-36R, is linked to the host response to bacterial and viral infections that induce exacerbations in these patients. Our studies will provide new insight into the role IL-36?/IL-36R in infection, disease exacerbation and determine the therapeutic benefit of blocking this pathway.