Characterization of SgK269, a master regulator of growth factor receptor signalling

细胞内受干扰的信号会导致多种疾病，包括癌症。SgK269是一种参与信号转导的支架蛋白，与乳腺癌、结肠癌和胰腺癌有关。通过确定SgK269支架的信号机制和功能，这项工作将为细胞信号转导的关键调控因子提供新的和重要的见解，并揭示可能用于癌症治疗的SgK269支架的潜在靶向治疗策略。

Perturbed signaling within a cell can cause multiple diseases, including cancer. SgK269 is a scaffold protein involved in signaling and implicated in breast, colon and pancreatic cancer. By determining the signaling mechanism and function of the SgK269 scaffold, this work will provide novel and important insights into a key regulator of cell signaling, and reveal potential strategies for therapeutic targeting of the SgK269 scaffold that could be utilized in cancer treatment.