A New Paradigm for Class I Cytokine Receptor Activation

第一类细胞因子受体包括30多种受体，具有控制代谢和炎症等多种功能。细胞因子受体是细胞上的分子开关，它接收来自其他细胞的信号并将该信号传递到细胞核以控制基因的调节。该项目将确定I类细胞因子受体的分子机制，并利用这些知识开发用于临床应用的调节这些受体的新方法。

Class I cytokine receptors include around 30 receptors with diverse functions such as controlling metabolism and inflammation. Cytokine receptors are molecular switches on cells that receive signals from other cells and transmit this signal into the cell’s nucleus to control the regulation of genes. This project will determine the molecular mechanisms involved in class I cytokine receptors and use this knowledge to develop novel ways to modulate these receptors for clinical applications.