A New Paradigm for Class I Cytokine Receptor Activation

I类细胞因子受体包括约30种具有不同功能的受体，例如控制代谢和炎症。细胞因子受体是细胞上的分子开关，其接收来自其他细胞的信号并将该信号传递到细胞核中以控制基因的调节。本项目将确定I类细胞因子受体的分子机制，并利用这些知识开发新的方法来调节这些受体的临床应用。

Class I cytokine receptors include around 30 receptors with diverse functions such as controlling metabolism and inflammation. Cytokine receptors are molecular switches on cells that receive signals from other cells and transmit this signal into the cell’s nucleus to control the regulation of genes. This project will determine the molecular mechanisms involved in class I cytokine receptors and use this knowledge to develop novel ways to modulate these receptors for clinical applications.