Regulation of cortical excitability by GABAB receptors

在大脑中，电活动要么兴奋，要么抑制神经细胞。兴奋被抑制所平衡。如果这两个过程变得不平衡，我们可能会失去意识或癫痫发作。这些极端的条件强调了大脑中兴奋和抑制之间的平衡的重要性。虽然关于兴奋的作用已经有了很多工作，但关于抑制的研究还很少。在这个项目提案中，我们将研究抑制如何调节大脑皮层的兴奋。

In the brain electrical activity either excites or inhibits nerve cells. Excitation is balanced by inhibition. If these two processes become unbalanced we can become unconscious or go into seizure. These extreme conditions emphasize the importance of the balance between excitation and inhibition in the brain. While there has been much work on the role of excitation, less is known about inhibition. In this project proposal we will investigate how inhibition regulates excitation in the cortex.