REGULATION OF HUMORAL IMMUNITY BY PI3K p110?

免疫系统通常会迅速做出反应，根除传染性病原体。然而，PI3KCD基因突变的患者无法控制某些细菌和病毒的感染，PI3KCD基因对免疫细胞内传递信息非常重要。我们将研究这些突变对B细胞的影响，B细胞是一种免疫细胞，它会产生抗体，与我们的身体结合并清除病原体。这将解释这种疾病的一些临床特征，并揭示潜在的新治疗方法。

The immune system usually rapidly responds to eradicate infectious pathogens. However patients with mutations in the gene PI3KCD, which is important for delivering messages within immune cells, are unable to control infections with some bacteria and viruses. We will study the effects of these mutations on B cells, the immune cells produce antibodies that bind to and remove pathogens from our body. This will explain some of the clinical features of this disease and reveal potential new treatments