Instrument for coating of nanoparticles

通过包覆合适的物质使纳米颗粒稳定和功能化是纳米颗粒许多成功应用的核心，无论是在分析目的、技术过程中还是在制药应用中。本提案的重点是通过包衣对药物颗粒进行功能化和稳定化。药物颗粒的包衣对制药应用如此重要有两个原因。它有助于稳定这些微小的颗粒，防止结块和凝结。这两个过程都发生在颗粒形成和储存过程中，导致不必要的修饰，从而影响产品的生物利用度。此外，正确的包衣可以用来实现靶向药物输送。一个简单的例子是药物的pH依赖释放，这可以通过与pH相关的聚合物包衣来实现。然而，目前，工程，特别是以受控方式包衣药物颗粒仍然是一个技术挑战。这严重限制了微粒药物制剂的适用性。本提案的主要目的是通过建立一种用于药物颗粒包衣的新装置来克服这一限制。主要目标是生产具有良好包衣的药物颗粒，并表征其物理化学性质。

The stabilization and functionalization of nanoparticles by coating with suitable substances is central to many successful applications of nanoparticles be it for analytical purposes, in technical processes, or for pharmaceutical applications. The present proposal focuses on functionalization and stabilization of drug particles by coating. There are two reasons why coating of drug particles is so central to pharmaceutical applications. It helps to stabilize these tiny particles against agglomeration and coagulation. Both processes happen during particle formation and during storage of the particles leading to unwanted modifications which affect the bioavalability of the product. Furthermore, the right coating can be used to achieve a targeted drug delivery. A simple example is the pH-dependent release of a drug which can be achieved by coating with a polymer with pH-dependent solubility.Currently, however, the engineering and in particular the coating of drug particles in a controlled manner still represent a technical challenge. This severely limits the applicability of particulate drug formulations. The main objective of the present proposal is to overcome this limitation by setting up a novel device for coating of drug particles. The main goals are to produce drug particles with a well defined coating and to characterize their physical-chemical properties.