Regulation of toxoplasma by the NLRP1 inflammasome

弓形虫是世界范围内的一种地方性病原体，在一些地区接近80%的人口，疾病负担很大，特别是免疫功能低下和怀孕的人。我们的初步数据确定了免疫细胞中检测弓形虫的一种受体蛋白。这可以击败寄生虫，但也会导致宿主的病理。本课题的研究结果将为弓形虫受体的识别奠定基础，对弓形虫病的治疗具有重要意义。

Toxoplasmosa is an endemic pathogen worldwide, approaching 80% of the population in some areas, with a large burden of disease, particularly of immunocompromised and pregnant individuals. Our preliminary data identifies a receptor protein in immune cells that detects Toxoplasma. This can defeat the parasite, but also causes pathology for the host. The outcome of our project will work out what part of Toxoplasma is recognized by this receptor, with significance for the treatment of Toxoplasmosis.