Relating genetic, biological, and behavioural markers of early vulnerability in conduct problem children.

这项研究将在大量有代表性的青少年行为问题儿童样本中进行第一次特定遗传风险测试。这些儿童代表了我们社区中第一个容易识别的高风险持续心理健康问题群体。在他们的数量中，极有可能是异质的亚群，它们将在一生中采取非常不同的轨迹。目前的研究建立在几年的发育研究的基础上，我们已经开发出了识别组内不同表型的方法。这项研究将确定这些亚型的遗传标记，并将其与情绪处理联系起来，作为心理健康问题和反社会行为发展风险的一般模型。研究结果将为遗传脆弱性模型提供信息，更重要的是，遗传风险与高危儿童基本信息处理方式的关系，从而有助于早期发现，早期干预和预防的方法。

This research will conduct the first test of specific genetic risk in a large and representative sample of young conduct problem children. These children represent the first readily identifiable group that are at high risk for ongoing mental health problems in our community. It is highly likely that within their numbers are heterogeneous subgroups that will take very different trajectories through life. The current study builds on several years of developmental research in which we have developed methods for identifying different phenotypes within the group. The study will identify genetic markers of these subtypes and relate these to emotional processing as a general model of risk in the development of mental health problems and antisocial behaviour. Findings will inform models of genetic vulnerability, and more importantly, the relationship of genetic risk to basic information processing styles in at-risk children, thus aiding methods for early detection, early intervention and prevention.