Research Fellowship

血小板是预防损伤或感染后出血所必需的关键血液成分。过度活跃或自发活跃的血小板会引起血栓和血块形成。我的实验室已经确定了血小板金属蛋白酶激活的新生理途径，这种酶调节血栓形成前血小板受体的表面水平。通过了解这种受体调节机制，我们可以独特地靶向血小板受体在血栓形成前病变的人。

Platelets are key blood elements that are essential for the prevention of bleeding in response to injury or infection. Overactive or spontaneously active platelets cause thrombosis and blood clot formation. My laboratory has identified new physiological pathways of activation of platelet metalloproteinases, the enzymes that regulate surface levels of the prothrombotic platelet receptors. By understanding this mechanism of receptor regulation, we can uniquely target platelet receptors in people with prothrombotic pathologies.