Respiratory phenotyping for new targeted approaches to treat sleep apnoea

9%的澳大利亚人患有阻塞性睡眠呼吸暂停(OSA)。阻塞性睡眠呼吸暂停综合征有几个原因。未经治疗的阻塞性睡眠呼吸暂停综合征与严重的健康后果有关。50%的阻塞性睡眠呼吸暂停患者可耐受持续气道正压治疗。迫切需要新的治疗方法。这项建议旨在使用和开发新的方法，以确定每个患者的OSA的原因，改进现有的治疗方法，并测试是否可以使用新的靶向治疗方法来治疗适当选择的OSA患者。

>9% of Australians have obstructive sleep apnoea (OSA). OSA has several causes. Untreated OSA is associated with major health consequences. <50% of OSA patients tolerate the main therapy, continuous positive airway pressure. New treatments are urgently required. This proposal aims to use & develop novel approaches to identify the causes of OSA on a per patient basis, improve current therapies & test if new targeted therapies can be used to treat OSA in appropriately selected patients.