The role of the central insulin-NPY pathway in the regulation of energy balance

众所周知，胰岛素在调节肝脏、肌肉和脂肪中的葡萄糖代谢中起着重要作用，但人们对胰岛素在大脑中的作用知之甚少。该项目旨在提高我们对胰岛素如何调节能量平衡和食欲的理解，识别大脑中涉及的确切神经网络，并了解肥胖病理的机制见解，为开发更有效和更安全的治疗方法提供手段。

Insulin is known for its role in the regulation of glucose metabolism in the liver, muscle and fat, however very little is known about the role of insulin in the brain. This project aims to improve our understanding on how insulin regulates energy balance and appetite and identifies the exact neuronal networks involved in the brain and to understand the mechanistic insights into the pathology of obesity, providing the means for the development of more effective and safer therapeutic approaches.