The role of chemokine signalling in maintenance of the latent HIV reservoir

HIV治疗研究旨在消除DNA中含有HIV的细胞。这些细胞具有更高水平的受体CCR6，通过其信号传导导致迁移到肠道并在肠道中集中。这种肠道迁移可能有助于维持艾滋病毒的水库，使易感细胞接近感染细胞。我们将评估阻断CCR6信号传导对实验室中HIV感染这些细胞的能力的影响，以及其对猕猴中类似病毒的储存库的影响。

HIV cure research aims to eliminate cells with HIV in their DNA. These cells have higher levels of a receptor, CCR6, signalling through which causes migration to and concentration in the gut. This gut migration may help to maintain the HIV reservoir by bringing susceptible cells close to infected cells. We will assess the effect of blocking CCR6 signalling on the ability to infect these cells with HIV in the laboratory and its effect on the reservoir of an analogous virus in macaques.