The role of Crim1 in growth factor activity and cell motility/adhesion.

crip1是一种新的蛋白，它可以调节生长因子的活性，从而影响许多器官的正常发育。它尤其与血管的正常发育有关。更好地了解生长因子活性是如何被Crim1调节的，将对几乎所有涉及这些生长因子的发育和疾病状态具有重要意义。Crim1连接几种不同生长因子通路活性的潜力可以解释生长因子反应的组织特异性差异。这些基本的理解进展将对许多疾病状态产生影响，包括肾脏疾病、血管疾病和癌症。

Crim1 is a novel protein which appears to regulate the activity of growth factors and therefore affects the normal development of a number of organs. It is particulrly involved in normal development of blood vessels. A greater understanding of how growth factor activity is modulated by Crim1 will have significance to almost every developmental and disease state involving such growth factors. The potential for Crim1 to link the activity of several distinct growth factor pathways may explain tissue specific differences in growth factor responses. These basic advances in understanding will have implications for many disease states, including renal disease, vascular disease and cancer.