Role of flavivirus-encoded small regulatory RNAs in virus-mosquito vector interactions
Role of flavivirus-encoded small regulatory RNAs in virus-mosquito vector interactions
批准号:
nhmrc : 1027110
负责人:
Prof Alexander Khromykh
金额:
$36.49万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31
中文摘要
蚊媒疾病是对人类健康的主要威胁。MicroRNAs是一种小的非编码核糖核酸(RNAs),在发育、癌症、细胞凋亡、免疫、长寿和病毒感染方面发挥着重要作用。我们建议从黄病毒中识别调控的microRNAs,并建立它们在载体-虫媒病毒相互作用中的潜在功能。该项目将使澳大利亚在发展最快的microRNA研究领域走在研究的前沿。
英文摘要
Mosquito-borne diseases are major threats to human health. MicroRNAs are small non-coding ribonucleic acids (RNAs) that play important roles in development, cancer, apoptosis, immunity, longevity, and viral infections. We propose to identify the regulatory microRNAs from flaviviruses and establish their potential function in vector-arboviruses interactions. The project will put Australia at the forefront of research in the most rapidly developing area of microRNA research.
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