Role of the lysosomal protein SCARB2 in kidney disease

尿液中蛋白质的损失是肾脏衰竭之前发生的最重要的事情之一。失去蛋白质似乎会损害肾脏，但我们仍然不确定它在大多数人中是如何发生的。我们正在研究细胞的“废物管理系统”，使它们能够摆脱不再需要的蛋白质。我们有一些证据表明这个系统在遗传性蛋白尿中是异常的，现在想知道这是否也是更常见疾病的问题。

Loss of protein in the urine is one of the most important things that happens before the kidneys fail. Losing protein seems to damage the kidneys, but we are still not sure how it happens in most people. We are studying the 'waste management system' of cells, that enables them to get rid of proteins that are no longer required. We have some evidence that this system is abnormal in inherited proteinuria and now want to find out if this is also a problem in more common diseases.