The Role of Osteopontin in Leukemia

虽然大多数白血病患者最初对化疗反应良好，但60%的患者死亡，因为治疗后白血病细胞存活导致疾病复发。我们已经发现了一种新的蛋白，骨桥蛋白（OPN），它可能允许白血病细胞存活，从而降低化疗根除疾病的能力。我们试图研究OPN在白血病中的作用，以期在未来开发靶向治疗。

While most leukemia patients initially respond well to chemotherapy, >60% die because the disease returns as a result of the survival of leukaemia cells following treatment. We have identified a new protein, osteopontin (OPN), that may allow the survival of leukaemia cells and therefore reduce the ability of chemotherapy to erradicate disease. We seek to examine the role of OPN in leukemia with a view toward developing targetted therapies in the future.