Role of sphingosine kinase 1 in PP2A-associated tumorigenesis

蛋白磷酸酶2A(PP2A)基因缺陷与实体瘤和白血病的发生发展密切相关。然而，PP2A缺陷导致癌症的确切机制仍不清楚。我们最近发现，致癌蛋白鞘氨酸激酶1(SK1)是PP2A的靶标。在这项研究中，我们将研究SK1在PP2A相关癌症中的作用。这些研究的成功结果将使SK1成为这些癌症治疗干预的目标。

Defects in protein phosphatase 2A (PP2A) are widely associated with the development of solid tumors and leukemia. The precise mechanisms whereby defects in PP2A lead to cancer, however, remain undefined. We have recently identified that the oncogenic protein sphingosine kinase 1 (SK1) as a target of PP2A. In this study we will examine the role of SK1 in PP2A-associated cancers. Successful outcomes in these studies will establish SK1 as a target for therapeutic intervention in these cancers.