The Role of Urotensin II in Diabetes-Associated Atherosclerosis

糖尿病患者最常死于中风或心脏病发作，我们需要确定是什么使他们更容易出现这些问题。最近发现的UII系统在糖尿病患者中增加，并在血管的病变部分被发现。因此，该项目的目的是利用两只独特的基因改变的小鼠和一种阻滞剂a来研究高胆固醇、糖尿病和UII缺失的影响，从而表征糖尿病背景下的UII系统。

People with diabetes most commonly die from stroke or heart attack and we need to determine what makes them more prone to these problems. The recently discovered UII system is increased in people with diabetes and has been found in diseased parts of blood vessels. Thus, the aim of this project is to characterise the UII system in the setting of diabetes using 2 unique genetically altered mice and a blocker a to study the effects of high cholesterol, diabetes and a deletion of UII.