Seeing is believing: imaging muscle maintenance and repair

我们将使用高端成像技术和我们最近创建的小鼠品系，在正常和再生成人肌肉的微环境中观察肌肉干细胞的体内行为。这将允许将细胞行为与信号通路的激活相关联，选择它们在卫星细胞激活中的可能作用。然后，我们将在卫星细胞龛中调节这些通路的活性，以评估它们的功能。

We will characterise the behaviour of muscle stem cells in vivo within their micro-environment in normal and regenerating adult muscles, using high-end imaging technologies and mouse lines that we recently created. This will allow correlating cellular behaviours with the activation of signaling pathways, chosen for their likely role in the activation of satellite cells. We will then modulate the activity of these pathways in the satellite cell niche to evaluate their function.